This course discusses the underlying science and physical plausibility (vs. flights of fancy) of prominent science fiction themes illustrated with movie/TV clips, videos and comics. Themes include giant insects/microbes and miniature humans in monster movies, faster-than-light travel (wormholes, warp drives), and time travel and its paradoxes. Other themes include “Are we alone?” (life in the universe, SETI, exoplanets), uploading consciousness, super intelligent AI and “Do we live in a simulation (matrix)?” It concludes with parallel universes (the multiverse.) General level course: The only requirement is curiosity about science fiction themes.